Abstract
This pilot study investigates the impact of video games on the mental health and behavior of children with autism spectrum disorder (ASD) in Syria. With the increasing prevalence of ASD and the growing popularity of video games, understanding the potential benefits and risks of gaming for children with ASD is crucial. The study explores whether video games can serve as a therapeutic tool or if they contribute to behavioral deterioration and addiction.
A sample of 50 children aged 6 to 12 years, diagnosed with ASD according to ICD-11 criteria, participated in the study. Data were collected through structured questionnaires completed by parents, assessing gaming habits, behavioural changes, and the level of video game addiction using the Internet Gaming Disorder Scale - Modified Short Form (IGDS9-SF). The study also evaluated the effects of replacing violent or repetitive games with more creative and interactive options, such as Minecraft and Super Mario Bros.
Results indicated that 90% of the children preferred playing video games over other activities, with boys showing a higher preference for violence and fighting games. Approximately 54% of the children exhibited signs of video game addiction, while 14% were classified as fully addicted. During gameplay, 74% of the children displayed negative behaviors, such as increased aggression and reduced communication. However, after switching to more constructive games, significant improvements in communication, social interaction, and behavior control were observed.
The study concludes that while video games offer potential benefits for children with ASD, including improved social skills, reduced anxiety, and enhanced problem-solving abilities, they also pose significant risks, particularly in terms of addiction and negative behavioral outcomes. The type of game played is a critical factor in determining the impact of gaming on children with ASD. A careful selection of games that promote creativity, cooperation, and cognitive development can help harness the positive aspects of gaming while mitigating its potential harms. This study highlights the need for further research into video game-based interventions tailored specifically for children with ASD, aiming to balance therapeutic benefits with the risks of excessive gaming.
References
Rastelli C, Falisi G, Gatto R, Galli M, Saccone E, Severino M, et al. Implant stability in different techniques of surgical sites preparation: an in vitro study. Oral Implantol (Rome). 2014;7(2):33–9.
SEM-EDX Analysis of Metal Particles Deposition from Surgical Burs after Implant Guided Surgery Procedures [Internet]. [cited 2025 Mar 6]. Available from: https://www.mdpi.com/2079-6412/12/2/240
Candotto V, Gabrione F, Oberti L, Lento D, Severino M. The role of implant-abutment connection in preventing bacterial leakage: a review. J Biol Regul Homeost Agents. 2019;33(3 Suppl. 1):129-134. DENTAL SUPPLEMENT.
Severino M, Caruso S, Rastelli S, Gatto R, Cutilli T, Pittari L, et al. Hand-Carried Ultrasonography Instrumentation in the Diagnosis of Temporomandibular Joint Dysfunction. Methods Protoc. 2021 Nov 6;4(4):81.
Signorini L, Marenzi G, Facente A, Marrelli B, Marano RM, Valletta A, et al. Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. Int J Med Sci [Internet]. 2023 Sep 18 [cited 2025 Mar 13];20(12):1527–34. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583188/
Guerra D, Severino M, Caruso S, Rastelli S, Gatto R. The Importance of Using Physical Tridimensional Models for the Management and Planning of Extended Osseous Odontogenic Lesions. Dent J (Basel). 2021 Nov 15;9(11):134.
Rastelli S, Capogreco M, D’Amario M, Falisi G, Severino M, Iacomino E. Pterygoid implants: a viable alternative for the rehabilitation of the posterior sectors of the atrophic maxilla. Oral and Implantology: A Journal of Innovations and Advanced Techniques for Oral Health [Internet]. 2024 Jun 28 [cited 2025 Feb 2];16(1):38–43. Available from: https://oimplantology.com/index.php/oimplantology/article/view/31
Excision of Lower Lip Mucocele Using Injection of Hydrocolloid Dental Impression Material in a Pediatric Patient: A Case Report [Internet]. [cited 2025 Mar 6]. Available from: https://www.researchgate.net/publication/352703721_Excision_of_Lower_Lip_Mucocele_Using_Injection_of_Hydrocolloid_Dental_Impression_Material_in_a_Pediatric_Patient_A_Case_Report
ResearchGate [Internet]. [cited 2025 Mar 6]. PTERIGOID IMPLANTS: a viable alternative for the rehabilitation of the posterior sectors of the atrophic maxilla. Available from: https://www.researchgate.net/publication/388259323_PTERIGOID_IMPLANTS_a_viable_alternative_for_the_rehabilitation_of_the_posterior_sectors_of_the_atrophic_maxilla
Severino M, Libonati A, Di Taranto V, Montemurro E, Campanella V. Comparative analysis of cleaning ability of two rotary instrument systems: Mtwo and ProTaper® universal. An in vitro scanning electron microscopic study. J Biol Regul Homeost Agents. 2019;33(3 Suppl. 1):51-61. DENTAL SUPPLEMENT.
Nota A, Tecco S, Caruso S, Severino M, Gatto R, Baldini A. Analysis of errors in following the rapid maxillary expansion activation protocol: An observational study. Eur J Paediatr Dent. 2019 Jun;20(2):116–8.
Rampino A, Garofalo M, Nuzzo T, Favia M, Saltarelli S, Masellis R, et al. Variations of blood D-serine and D-aspartate homeostasis track psychosis stages. Schizophrenia (Heidelb). 2024 Dec 19;10(1):115.
Fazio L, Pennacchio TC, Asselti MG, Semeraro C, Cassibba R, Pergola G, et al. La flessibilità psicologica come mediatore tra esposizione a stili genitoriali disfunzionali e autostima in un campione di adolescenti. 2024 [cited 2025 Mar 12]; Available from: https://ricerca.uniba.it/handle/11586/520500
Petruzzelli MG, Marzulli L, Margari F, De Giacomo A, Gabellone A, Giannico OV, et al. Vitamin D Deficiency in Autism Spectrum Disorder: A Cross-Sectional Study. Dis Markers. 2020;2020:9292560.
Petruzzelli MG, Margari M, Peschechera A, de Giambattista C, De Giacomo A, Matera E, et al. Hyperprolactinemia and insulin resistance in drug naive patients with early onset first episode psychosis. BMC Psychiatry. 2018 Aug 1;18(1):246.
De Giacomo A, Pedaci C, Palmieri R, Simone M, Costabile A, Craig F. Psychological impact of the SARS-CoV-2 pandemic in children with neurodevelopmental disorders and their families: evaluation before and during covid-19 outbreak among an Italian sample. Riv Psichiatr. 2021;56(4):205–10.
Filosi M, Kam-Thong T, Essioux L, Muglia P, Trabetti E, Spooren W, et al. Transcriptome signatures from discordant sibling pairs reveal changes in peripheral blood immune cell composition in Autism Spectrum Disorder. Transl Psychiatry. 2020 Apr 14;10(1):106.
Boulkedid R, Abdou AY, Desselas E, Monégat M, de Leeuw TG, Avez-Couturier J, et al. The research gap in chronic paediatric pain: A systematic review of randomised controlled trials. Eur J Pain. 2018 Feb;22(2):261–71.
Margari L, De Giacomo A, Craig F, Palumbi R, Peschechera A, Margari M, et al. Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study. Neuropsychiatr Dis Treat. 2018;14:1871–6.
L’Abate L, De Giacomo P, McCarty F, De Giacomo A, Verrastro G. Evaluating Three Models of Intimate Relationships. Contemporary Family Therapy [Internet]. 2000 Mar 1 [cited 2025 Mar 13];22(1):103–22. Available from: https://doi.org/10.1023/A:1007726717603
Piras C, Mussap M, Noto A, De Giacomo A, Cristofori F, Spada M, et al. Alterations of the Intestinal Permeability are Reflected by Changes in the Urine Metabolome of Young Autistic Children: Preliminary Results. Metabolites. 2022 Jan 23;12(2):104.
de Leeuw TG, Mangiarini L, Lundin R, Kaguelidou F, van der Zanden T, Pasqua OD, et al. Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial. Trials. 2019 Jan 15;20(1):49.
De Giacomo A, Medicamento S, Pedaci C, Giambersio D, Giannico OV, Petruzzelli MG, et al. Peripheral Iron Levels in Autism Spectrum Disorders vs. Other Neurodevelopmental Disorders: Preliminary Data. Int J Environ Res Public Health. 2022 Mar 28;19(7):4006.
Simone M, De Giacomo A, Palumbi R, Palazzo C, Lucisano G, Pompamea F, et al. Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Potential Diagnostic Biomarkers in Autism Spectrum Disorders: A Preliminary Study. Int J Mol Sci. 2023 Feb 3;24(3):3057.
Margari F, Petruzzelli MG, Lecce PA, Todarello O, De Giacomo A, Lucarelli E, et al. Familial liability, obstetric complications and childhood development abnormalities in early onset schizophrenia: a case control study. BMC Psychiatry. 2011 Apr 14;11:60.
Ventura G, Calvano CD, Porcelli V, Palmieri L, De Giacomo A, Xu Y, et al. Phospholipidomics of peripheral blood mononuclear cells (PBMCs): the tricky case of children with autism spectrum disorder (ASD) and their healthy siblings. Anal Bioanal Chem. 2020 Oct;412(25):6859–74.
Portoghese C, Buttiglione M, De Giacomo A, Lafortezza M, Lecce PA, Martinelli D, et al. Leiter-R versus developmental quotient for estimating cognitive function in preschoolers with pervasive developmental disorders. Neuropsychiatr Dis Treat. 2010 Sep 7;6:337–42.
De Giacomo P, L’Abate L, Margari F, De Giacomo A, Santamato W, Masellis R. Sentences with Strong Psychological Impact in Psychotherapy: Research in Progress. J Contemp Psychother [Internet]. 2008 Jun 1 [cited 2025 Mar 13];38(2):65–72. Available from: https://doi.org/10.1007/s10879-007-9069-6
Engelhardt CR, Mazurek MO, Sohl K. Media use and sleep among boys with autism spectrum disorder, ADHD, or typical development. Pediatrics. 2013 Dec;132(6):1081–9.
Inchingolo AM, Inchingolo AD, Latini G, Garofoli G, Sardano R, De Leonardis N, et al. Caries prevention and treatment in early childhood: comparing strategies. A systematic review. Eur Rev Med Pharmacol Sci. 2023 Nov;27(22):11082–92.
Inchingolo F, Tatullo M, Abenavoli FM, Marrelli M, Inchingolo AD, Villabruna B, et al. Severe anisocoria after oral surgery under general anesthesia. Int J Med Sci. 2010 Sep 10;7(5):314–8.
Mazurek MO, Engelhardt CR. Video game use in boys with autism spectrum disorder, ADHD, or typical development. Pediatrics. 2013 Aug;132(2):260–6.
Engelhardt CR, Mazurek MO. Video game access, parental rules, and problem behavior: a study of boys with autism spectrum disorder. Autism. 2014 Jul;18(5):529–37.
Abreu RR, Rocha RL, Lamounier JA, Guerra AFM. Etiology, clinical manifestations and concurrent findings in mouth-breathing children. J Pediatr (Rio J). 2008;84(6):529–35.
Aguilera SB, Brown L, Perico VA. Aesthetic Treatment of Bruxism. J Clin Aesthet Dermatol. 2017 May;10(5):49–55.
Agustin TP, Sutadi H, Bachtiar BM, Rizal MF. Proportion of Streptococcus mutans, Streptococcus sanguinis, and Candida albicans in Early Childhood Caries: Evaluation by qPCR. Open Dentistry Journal [Internet]. 2024 [cited 2025 Jan 7];18(e18742106290568). Available from: http://www.scopus.com/inward/record.url?scp=85186554562&partnerID=8YFLogxK
Aizenbud D, Peled M, Figueroa AA. A Combined Orthodontic and Surgical Approach in Osteogenesis Imperfecta and Severe Class III Malocclusion: Case Report. Journal of Oral and Maxillofacial Surgery [Internet]. 2008 May 1 [cited 2025 Feb 2];66(5):1045–53. Available from: https://www.joms.org/article/S0278-2391(08)00046-3/abstract
Alfieri V, Myasoedova VA, Vinci MC, Rondinelli M, Songia P, Massaiu I, et al. The Role of Glycemic Variability in Cardiovascular Disorders. Int J Mol Sci. 2021 Aug 4;22(16):8393.
AlSarhan M, AlJasser R, AlOraini S, Alotaibi DH, Alsinaidi AA, Habib SR. Relationship of Self-perceived Stress and Expression of Salivary Cortisol in Relation to Gender and Academic Levels among Dental Students. TODENTJ [Internet]. 2024 Feb 14 [cited 2025 Jan 7];18(1):e18742106282255. Available from: https://opendentistryjournal.com/VOLUME/18/ELOCATOR/e18742106282255/
Alzahabi R, Becker MW. The association between media multitasking, task-switching, and dual-task performance. J Exp Psychol Hum Percept Perform. 2013 Oct;39(5):1485–95.
Amruthesh S. Dentistry and Ayurveda--III (basics-ama, immunity, ojas, rasas, etiopathogenesis and prevention). Indian J Dent Res. 2007;18(3):112–9.
Anavi Y, Gal G, Silfen R, Calderon S. Palatal rotation-advancement flap for delayed repair of oroantral fistula: a retrospective evaluation of 63 cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology [Internet]. 2003 Nov 1 [cited 2025 Jan 9];96(5):527–34. Available from: https://www.sciencedirect.com/science/article/pii/S1079210403004700
Anger JT, Weinberg A, Suttorp MJ, Litwin MS, Shekelle PG. Outcomes of intravesical botulinum toxin for idiopathic overactive bladder symptoms: a systematic review of the literature. J Urol. 2010 Jun;183(6):2258–64.
Aravinth V, Aswath Narayanan MB, Ramesh Kumar SG, Selvamary AL, Sujatha A. Comparative evaluation of salt water rinse with chlorhexidine against oral microbes: A school-based randomized controlled trial. J Indian Soc Pedod Prev Dent. 2017;35(4):319–26.
Arora K, Kaur N, Kaur G, Garg U. Knowledge, Awareness, and Attitude in Using Dental Implants as an Option in Replacing Missing Teeth Among Dental Patients: Survey-Based Research in a Dental Teaching Hospital in Derabassi, Punjab. Cureus [Internet]. [cited 2025 Feb 2];14(7):e27127. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392853/
Arrigoni R, Ballini A, Santacroce L, Cantore S, Inchingolo A, Inchingolo F, et al. Another Look at Dietary Polyphenols: Challenges in Cancer Prevention and Treatment. Curr Med Chem. 2022;29(6):1061–82.
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015 Dec;33(8):1582–614.
Avvanzo P, Ciavarella D, Avvanzo A, Giannone N, Carella M, Lo Muzio L. Immediate placement and temporization of implants: three- to five-year retrospective results. J Oral Implantol. 2009;35(3):136–42.
Baeza M, Garrido M, Hernández-Ríos P, Dezerega A, García-Sesnich J, Strauss F, et al. Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study. Journal of Clinical Periodontology [Internet]. 2016 [cited 2025 Jan 26];43(1):34–45. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.12479
Baimuratova M, Shertayeva A, Madraimov N, Erkebay R, Diusebayev E. DISEASES OF PERIODONTAL TISSUES: MODERN CHALLENGES OF THE TIME. Georgian Med News. 2023 Mar;(336):126–31.
Ballini A, Cantore S, Farronato D, Cirulli N, Inchingolo F, Papa F, et al. Periodontal disease and bone pathogenesis: the crosstalk between cytokines and porphyromonas gingivalis. J Biol Regul Homeost Agents. 2015;29(2):273–81.
Ballini A, Cantore S, Fotopoulou EA, Georgakopoulos IP, Athanasiou E, Bellos D, et al. Combined sea salt-based oral rinse with xylitol in orthodontic patients: clinical and microbiological study. J Biol Regul Homeost Agents. 2019 Feb;33(1):263–8.
Ballini A, Cantore S, Saini R, Pettini F, Fotopoulou EA, Saini SR, et al. Effect of activated charcoal probiotic toothpaste containing Lactobacillus paracasei and xylitol on dental caries: a randomized and controlled clinical trial. J Biol Regul Homeost Agents. 2019 Jun;33(3):977–81.
Ballini A, Cantore S, Scacco S, Perillo L, Scarano A, Aityan SK, et al. A comparative study on different stemness gene expression between dental pulp stem cells vs. dental bud stem cells. Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1626–33.
Ballini A, Di Benedetto A, De Vito D, Scarano A, Scacco S, Perillo L, et al. Stemness genes expression in naïve vs. osteodifferentiated human dental-derived stem cells. Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2916–23.
Ballini A, Gnoni A, De Vito D, Dipalma G, Cantore S, Gargiulo Isacco C, et al. Effect of probiotics on the occurrence of nutrition absorption capacities in healthy children: a randomized double-blinded placebo-controlled pilot study. Eur Rev Med Pharmacol Sci. 2019 Oct;23(19):8645–57.
Ballini A, Cantore S, Signorini L, Saini R, Scacco S, Gnoni A, et al. Efficacy of Sea Salt-Based Mouthwash and Xylitol in Improving Oral Hygiene among Adolescent Population: A Pilot Study. Int J Environ Res Public Health. 2020 Dec 23;18(1):44.
Campanella V, Syed J, Santacroce L, Saini R, Ballini A, Inchingolo F. Oral probiotics influence oral and respiratory tract infections in pediatric population: a randomized double-blinded placebo-controlled pilot study. Eur Rev Med Pharmacol Sci. 2018 Nov;22(22):8034–41.
Campobasso A, Lo Muzio E, Battista G, Ciavarella D, Crincoli V, Lo Muzio L. Taxonomic Analysis of Oral Microbiome during Orthodontic Treatment. Int J Dent. 2021;2021:8275181.
Cantore S, Ballini A, De Vito D, Abbinante A, Altini V, Dipalma G, et al. Clinical results of improvement in periodontal condition by administration of oral probiotics. J Biol Regul Homeost Agents. 2018;32(5):1329–34.
Cantore S, Ballini A, Farronato D, Malcangi G, Dipalma G, Assandri F, et al. Evaluation of an oral appliance in patients with mild to moderate obstructive sleep apnea syndrome intolerant to continuous positive airway pressure use: Preliminary results. Int J Immunopathol Pharmacol. 2016 Jun;29(2):267–73.
Cantore S, Mirgaldi R, Ballini A, Coscia MF, Scacco S, Papa F, et al. Cytokine gene polymorphisms associate with microbiogical agents in periodontal disease: our experience. Int J Med Sci. 2014;11(7):674–9.
Carnevalli ACR, Dias da Silva SMS, da Silva Leite LS, de Moura VT, Kitakawa D, da Silva Peralta F, et al. A Clinical Appearance of Traumatic Fibroma with a Distinct and Rare Histological Diagnosis –insights of Pseudo Perineurioma – Case Report. [cited 2025 Jan 7]; Available from: https://opendentistryjournal.com/VOLUME/18/ELOCATOR/e18742106284558/
Carta MG, Cossu G, Pintus E, Zoccheddu R, Callia O, Conti G, et al. Active elderly and health-can moderate exercise improve health and wellbeing in older adults? Protocol for a randomized controlled trial. Trials. 2021 May 7;22(1):331.
Carta MG, Kalcev G, Scano A, Primavera D, Orrù G, Gureye O, et al. Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition? Brain Sci. 2022 Dec 22;13(1):16.
Carta MG, Romano F, Orrù G. The True Challenges of the Covid-19 Epidemics: The Need for Essential Levels of Care for All. Open Respir Med J [Internet]. 2020 Mar 16 [cited 2025 Jan 4];14:8–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254820/
Casu C, Orrù G, Scano A. Curcumin/H2O2 photodynamically activated: an antimicrobial time-response assessment against an MDR strain of Candida albicans. Eur Rev Med Pharmacol Sci. 2022 Dec;26(23):8841–51.
Casu C, Mannu C. Atypical Afta Major Healing after Photodynamic Therapy. Case Rep Dent. 2017;2017:8517470.
Casu C, Mosaico G, Natoli V, Scarano A, Lorusso F, Inchingolo F. Microbiota of the Tongue and Systemic Connections: The Examination of the Tongue as an Integrated Approach in Oral Medicine. Hygiene [Internet]. 2021 Sep [cited 2024 Dec 20];1(2):56–68. Available from: https://www.mdpi.com/2673-947X/1/2/6
Casu C, Murgia MS, Orrù G, Scano A. Photodynamic therapy for the successful management of cyclosporine-related gum hypertrophy: A novel therapeutic option. J Public Health Res [Internet]. 2022 Oct 6 [cited 2025 Jan 4];11(4):22799036221116177. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549190/
Cavalca V, Veglia F, Squellerio I, Marenzi G, Minardi F, De Metrio M, et al. Glutathione, vitamin E and oxidative stress in coronary artery disease: relevance of age and gender. Eur J Clin Invest. 2009 Apr;39(4):267–72.
Cazzolla AP, Campisi G, Lacaita GM, Cuccia MA, Ripa A, Testa NF, et al. Changes in pharyngeal aerobic microflora in oral breathers after palatal rapid expansion. BMC Oral Health. 2006 Jan 21;6:2.
Cenzato N, Farronato M, Tartaglia FC, Giannini L, Inchingolo AM, Dipalma G, et al. Soft Tissue Facial Morphology in Growing Patients with Different Occlusal Classes. J Pers Med. 2024 Oct 7;14(10):1042.
Ceratti C, Maspero C, Consonni D, Caprioglio A, Connelly ST, Inchingolo F, et al. Cone-Beam Computed Tomographic Assessment of the Mandibular Condylar Volume in Different Skeletal Patterns: A Retrospective Study in Adult Patients. Bioengineering (Basel). 2022 Mar 2;9(3):102.
Ceraulo S, Carini F, Viscardi D, Cesca A, Biagi R. Computer-guided Surgery in Anterior Esthetic Area with Autologous Deciduous Tooth-Derived Material: Case Report. 2024 [cited 2025 Jan 7]; Available from: https://boa.unimib.it/handle/10281/507441
Charitos IA, Del Prete R, Inchingolo F, Mosca A, Carretta D, Ballini A, et al. What we have learned for the future about COVID-19 and healthcare management of it? Acta Biomed. 2020 Jul 22;91(4):e2020126.
Chen F, Zhang W, Mfarrej MFB, Saleem MH, Khan KA, Ma J, et al. Breathing in danger: Understanding the multifaceted impact of air pollution on health impacts. Ecotoxicology and Environmental Safety [Internet]. 2024 Jul 15 [cited 2025 Jan 7];280:116532. Available from: https://www.sciencedirect.com/science/article/pii/S0147651324006080
Cheng L, Liu W, Zhang T, Xu T, Shu YX, Yuan B, et al. Evaluation of the effect of a toothpaste containing Pudilan extract on inhibiting plaques and reducing chronic gingivitis: A randomized, double-blinded, parallel controlled clinical trial. Journal of Ethnopharmacology [Internet]. 2019 Aug 10 [cited 2025 Jan 10];240:111870. Available from: https://www.sciencedirect.com/science/article/pii/S0378874118347688
Cho YK, Choi MG, Choi SC, Lee KM, Kim TO, Park SH, et al. Randomised clinical trial: tegoprazan, a novel potassium-competitive acid blocker, or lansoprazole in the treatment of gastric ulcer. Aliment Pharmacol Ther. 2020 Sep;52(5):789–97.
Choi YJ, Lee YC, Kim JM, Kim JI, Moon JS, Lim YJ, et al. Triple Therapy-Based on Tegoprazan, a New Potassium-Competitive Acid Blocker, for First-Line Treatment of Helicobacter pylori Infection: A Randomized, Double-Blind, Phase III, Clinical Trial. Gut Liver. 2022 Jul 15;16(4):535–46.
Chouikh F, Dierks EJ. The Buccal Fat Pad Flap. Oral Maxillofac Surg Clin North Am. 2021 May;33(2):177–84.
Ciavarella D, Guiglia R, Campisi G, Di Cosola M, Di Liberto C, Sabatucci A, et al. Update on gingival overgrowth by cyclosporine A in renal transplants. Med Oral Patol Oral Cir Bucal. 2007 Jan 1;12(1):E19-25.
Cirulli N, Ballini A, Cantore S, Farronato D, Inchingolo F, Dipalma G, et al. MIXED DENTITION SPACE ANALYSIS OF A SOUTHERN ITALIAN POPULATION: NEW REGRESSION EQUATIONS FOR UNERUPTED TEETH. J Biol Regul Homeost Agents. 2015;29(2):515–20.
Cirulli N, Inchingolo AD, Patano A, Ceci S, Marinelli G, Malcangi G, et al. Innovative Application of Diathermy in Orthodontics: A Case Report. Int J Environ Res Public Health. 2022 Jun 17;19(12):7448.
Coates SJ, Enbiale W, Davis MDP, Andersen LK. The effects of climate change on human health in Africa, a dermatologic perspective: a report from the International Society of Dermatology Climate Change Committee. Int J Dermatol. 2020 Mar;59(3):265–78.
Collatuzzo G, Visci G, Violante FS, Porru S, Spiteri G, Monaco MGL, et al. Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers - ORCHESTRA project. Front Immunol. 2022;13:986085.
Coloccia G, Inchingolo AD, Inchingolo AM, Malcangi G, Montenegro V, Patano A, et al. Effectiveness of Dental and Maxillary Transverse Changes in Tooth-Borne, Bone-Borne, and Hybrid Palatal Expansion through Cone-Beam Tomography: A Systematic Review of the Literature. Medicina (Kaunas). 2021 Mar 19;57(3):288.
Contaldo M, Lajolo C, Di Petrillo M, Ballini A, Inchingolo F, Serpico R, et al. Analysis of lip pigmentations by reflectance confocal microscopy: report of two cases. J Biol Regul Homeost Agents. 2019;33(3 Suppl. 1):19-25. DENTAL SUPPLEMENT.
Contaldo M, Luzzi V, Ierardo G, Raimondo E, Boccellino M, Ferati K, et al. Bisphosphonate-related osteonecrosis of the jaws and dental surgery procedures in children and young people with osteogenesis imperfecta: A systematic review. J Stomatol Oral Maxillofac Surg. 2020 Nov;121(5):556–62.
Contaldo M, Boccellino M, Zannini G, Romano A, Sciarra A, Sacco A, et al. Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View. J Oncol. 2020;2020:9587971.
Contaldo M, De Rosa A, Nucci L, Ballini A, Malacrinò D, La Noce M, et al. Titanium Functionalized with Polylysine Homopolymers: In Vitro Enhancement of Cells Growth. Materials (Basel) [Internet]. 2021 Jul 3 [cited 2024 Dec 20];14(13):3735. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269806/
Stein LI, Polido JC, Cermak SA. Oral care and sensory over-responsivity in children with autism spectrum disorders. Pediatr Dent. 2013;35(3):230–5.
Wang J, Huang H, Liu C, Zhang Y, Wang W, Zou Z, et al. Research Progress on the Role of Vitamin D in Autism Spectrum Disorder. Front Behav Neurosci [Internet]. 2022 May 10 [cited 2025 Mar 14];16:859151. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128593/
Abdulamir HA, Abdul-Rasheed OF, Abdulghani EA. Serotonin and serotonin transporter levels in autistic children. Saudi Med J. 2018 May;39(5):487–94.
Stein LI, Polido JC, Mailloux Z, Coleman GG, Cermak SA. Oral care and sensory sensitivities in children with autism spectrum disorders. Spec Care Dentist. 2011;31(3):102–10.
Ikehara M, Kashida N, Ishida R, Mizui R, Makinodan M, Yamamuro K. Influence of self-esteem on health-related quality of life in children and adolescents with autism spectrum disorders. Psychiatry and Clinical Neurosciences Reports [Internet]. 2025 [cited 2025 Mar 14];4(1):e70079. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/pcn5.70079
Aldulaijan HA, Cohen RE, Stellrecht EM, Levine MJ, Yerke LM. Relationship between hypothyroidism and periodontitis: A scoping review. Clin Exp Dent Res [Internet]. 2019 Sep 26 [cited 2024 Mar 26];6(1):147–57. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025985/
Alenezi AA, Aldokhayel HS. The impact of dental fear on the dental attendance behaviors: A retrospective study. J Family Med Prim Care [Internet]. 2022 Oct [cited 2024 Mar 23];11(10):6444–50. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810871/
Almeida-da-Silva CLC, Matshik Dakafay H, Liu K, Ojcius DM. Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells. Int J Mol Sci. 2021 Jul 18;22(14):7669.
Brenner J, Pan Z, Mazefsky C, Smith KA, Gabriels R, Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC). Behavioral Symptoms of Reported Abuse in Children and Adolescents with Autism Spectrum Disorder in Inpatient Settings. J Autism Dev Disord. 2018 Nov;48(11):3727–35.
Hoover DW, Kaufman J. Adverse childhood experiences in children with autism spectrum disorder. Curr Opin Psychiatry. 2018 Mar;31(2):128–32.
Lei J, Leigh E, Charman T, Russell A, Hollocks MJ. Exploring the association between social camouflaging and self- versus caregiver-report discrepancies in anxiety and depressive symptoms in autistic and non-autistic socially anxious adolescents. Autism. 2024 Oct;28(10):2657–74.
Jafari T, Rostampour N, Fallah AA, Hesami A. The association between mercury levels and autism spectrum disorders: A systematic review and meta-analysis. J Trace Elem Med Biol. 2017 Dec;44:289–97.
Roberts AL, Galea S, Austin SB, Cerda M, Wright RJ, Rich-Edwards JW, et al. Posttraumatic stress disorder across two generations: concordance and mechanisms in a population-based sample. Biol Psychiatry. 2012 Sep 15;72(6):505–11.
Inchingolo F, Tatullo M, Marrelli M, Inchingolo AD, Corelli R, Inchingolo AM, et al. Clinical case-study describing the use of skin-perichondrium-cartilage graft from the auricular concha to cover large defects of the nose. Head Face Med. 2012 Mar 19;8:10.
Inchingolo AD, Dipalma G, Inchingolo AM, Malcangi G, Santacroce L, D’Oria MT, et al. The 15-Months Clinical Experience of SARS-CoV-2: A Literature Review of Therapies and Adjuvants. Antioxidants (Basel). 2021 May 31;10(6):881.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Oussama Ali Abdallah, Bojan Radic , Lynn Almasri, Andrea Palermo , Andrea De Giacomo , Martina Grazia Asselti, Fabio Luis Bunemer Guerra , Ana Júlia de Paula Guerra, Laura Ferrante , Alexandra Semjonova, Massimo Corsalini , Francesco Inchingolo , Angelo Michele Inchingolo , Gianna Dipalma , Alessio Danilo Inchingolo