Abstract
The patient with cleft lip and palate represents a continuous challenge for the maxillofacial surgeon and the dentist.
This type of patient requires a multidisciplinary team approach, from the initial stages of the rehabilitation process, to minimize the deformations caused by adhesions.
Bone grafting represents a valid possibility for achieving these objectives in the various surgical procedures for restoring mandibular integrity.
In this clinical case, the authors present the multidisciplinary approach to a case of cleft lip and palate, resolved with a revascularized fibula graft in the premaxillary area and subsequent implant-prosthetic therapy with a 15-year follow-up.
Using new technologies in diagnosis and treatment allows patients to face surgical challenges with greater confidence and achieve the desired results.
References
Cicconetti, A., Passaretti, A., Rastelli, C., Rastelli, E., Falisi, G. Innovations in oral and maxillofacial surgery: Biomimetics meets physiology. Journal of Biological Regulators and Homeostatic Agents, 2019, 33(5), pp. 1609–1614
Falisi, G., Cutilli, T., Rastelli, E., Bernardi, S., Continenza, M.A., Vittorini Velasquez, P., Severino, M., Rare case of inverted impacted canine in infra orbitary position requiring surgical therapy on ORAL and Implantology, 2019, 12(1), pp. 36–41
Di Paolo, C., Papi, M.D.P., Falisi, G., ... Polimeni, A., Fiorini, A. Subjects with temporomandibular joint disc displacement and body posture assessment via raster stereography: A pilot case-control study European Review for Medical and Pharmacological Sciences, 2020, 24(17), pp. 8703–8712
Fabiano, F., Matarese, G., Bollero, P., ... Dipalma, G., Inchingolo, F. Clinical decision-making review on magnetic attachments versus mechanical attachments in dental prosthetics Australasian Medical Journal, 2017, 10(11), pp. 944–950
Vittorini-Velasquez, P., Falisi, G., Galli, M., Gallegos-Rivera, J.C. Self-bone graft and simultaneous application of implants in the upper jawbone. (Fit lock technique). Acta odontológica latinoamericana : AOL, 2011, 24(2), pp. 163–167
Scarano, A., Leo, L., Lorusso, F., ... Greco Lucchina, A., Di Carmine, M.S. Topical hemostatic agents in oral surgery: a narrative review European Review for Medical and Pharmacological Sciences, 2023, 27(3), pp. 135–140
Di Giacomo, P., Di Paolo, C., Qorri, E., ... Manes Gravina, G., Falisi, G. Conservative Therapies for TMJ Closed Lock: A Randomized Controlled Trial Journal of Clinical Medicine, 2022, 11(23), 7037
Lorusso, F., Mortellaro, C., Greco Lucchina, A., ... Di Carmine, M.S., Scarano, A.
Wettability of Mg-HA/Chitosan-based membrane surfaces: blood vs. autologous platelet liquid (APL) European Review for Medical and Pharmacological Sciences, 2023, 27(3), pp. 153–161
Borgonovo A, Grandi T, Vassallo S, Signorini L. Extrasinus Zygomatic Implants for the Immediate Rehabilitation of the Atrophic Maxilla: 1-Year Postloading Results From a Multicenter Prospective Cohort Study. J Oral Maxillofac Surg. 2021 Feb;79(2):356-365
Signorini L, Faustini F, Samarani R, Grandi T. Immediate fixed rehabilitation supported by pterygoid implants for participants with severe maxillary atrophy: 1-Year postloading results from a prospective cohort study. J Prosthet Dent. 2021 Jul;126(1):67-75
Bernardi, S., Qorri, E., Botticelli, G., ... Rastelli, C., Falisi, G. Use of electrical field for biofilm implant removal European Review for Medical and Pharmacological Sciences, 2023, 27(3), pp. 114–121
Falisi, G., Qorri, E., Botticelli, G., ... Mondragon, M., Di Giacomo, P.
STABILIZATION OF THE LOWER DENTURE THROUGH THE USE OF FINE MINI-IMPLANTS: RETROSPECTIVE STUDY European Journal of Musculoskeletal Diseases, 2024, 13(2), pp. S1–S7
Botticelli, G., Pizzolante, T., Capogreco, M., ... Testa, G., Rastelli, S. Clinical and radiographical evaluation of two agenesis alveolar ridges of upper lateral incisors. A case report with 5 years follow-up ORAL and Implantology, 2024, 16(3), pp. 107–112
Gerardi, D., Bernardi, S., Bruni, A., Falisi, G., Botticelli, G. Characterization and morphological methods for oral biofilm visualization: where are we nowadays? AIMS Microbiology, 2024, 10(2), pp. 391–414
Varvara, G., Angiolani, F., Rinaldi, F., ... Botticelli, G., Pizzolante, T. COMPLICATION OF THE EXTRACTION OF MAXILLARY ANTERIOR SUPERNUMERARY TEETH: THE ACCIDENTAL EXTRACTION OF THE PERMANENT TOOTH BUD Bulletin of Stomatology and Maxillofacial Surgery, 2025, 21(1), pp. 29–35
Ferrazzano, G.F., Di Fabio, G., Gatto, R., ... Botticelli, G., Caruso, S. Effectiveness and Tolerability of a New Formulation of a Topical Anesthetic in Reduction of Pain and Parents’ Satisfaction in Pediatric Dentistry Children, 2023, 10(3), 444
Botticelli, G., Kostandini, D., Pizzolante, T., ... Scarano, A., Rastelli, S. USE OF THE ELECTRICAL DEVICE ON DENTAL IMPLANT’S BACTERIAL BIOFILM: A PRELIMINARY IN VITRO STUDY Bulletin of Stomatology and Maxillofacial Surgery, 2025, 21(2), pp. 5–12
Pizzolante, T., Botticelli, G., Severino, M., Caporro, G., Rastelli, S. THE USE OF HYPNOSIS IN DENTISTRY IN ANXIOUS PATIENTS. SYSTEMATIC REVIEW OF THE LITERATURE OF THE LAST 5 YEARS Bulletin of Stomatology and Maxillofacial Surgery, 2025, 21(2), pp. 99–113
Negri, P., Russomanno, N., Eramo, S., ... Viarchi, A., Severino, M. ANALYSIS OF RESISTANCE OF ORTHODONTIC COMPONENTS TO MOUTHWASHES, DISINFECTANTS AND STERILIZER: AN IN VITRO STUDY Bulletin of Stomatology and Maxillofacial Surgery, 2025, 21(1), pp. 19–28
Rastelli, S., Caporro, G., Severino, M., ... Gasbarri, A., Pizzolante, T. Anatomically guided full arch implant-prosthetic rehabilitations ORAL and Implantology, 2024, 16(3), pp. 146–152
Memè, L., Pizzolante, T., Saggiomo, A.P., ... Inchingolo, F., Rastelli, S. The use of ozone therapy for the treatment and post-surgical management of patients treated with bilateral extraction of the included third mandibular molars ORAL and Implantology, 2024, 16(3), pp. 124–132
Rastelli, S., D’amario, M., Iacomino, E., ... Guerra, D., Capogreco, M. Early diagnosis of Sjögren’s syndrome: the role of biopsy of the minor salivary glands Journal of Biological Regulators and Homeostatic Agents, 2022, 36, pp. 81–86
Guerra, D., D’amario, M., Lacarbonara, M., ... Lupi, E., Capogreco, M. 3D printed anatomical models in the preliminary planification and execution of complex implant placement: a case report Journal of Biological Regulators and Homeostatic Agents, 2022, 36(2), pp. 65–70
Pizzolante, T., Saggiomo, A.P., Principi, M., ... Jolla, E., Rastelli, S. Minimal invasive sinus elevation (MISE), a different approach for maxillary sinus lift surgery ORAL and Implantology, 2024, 16(3), pp. 140–145
Franco, R., Lupi, E., Iacomino, E., ... Santos, J.M.M., D’Amario, M. Low-Level Laser Therapy for the Treatment of Oral Mucositis Induced by Hematopoietic Stem Cell Transplantation: A Systematic Review with Meta-Analysis Medicina (Lithuania), 2023, 59(8), 1413
Romano, L., Giuliani, A., Muselli, M., ... De Nardi, P., Vistoli, F. Toward Environmentally sustainable surgery: Waste recycling in general surgery operating room. Preliminary cognitive audit World Journal of Surgery, 2024, 48(11), pp. 2637–2643
Taglieri, G., Arrizza, L., Daniele, V., ... Iacomino, E., Ventura, L. Application of nanoparticles in consolidation treatments of archeological bones Pathologica, 2015, 107(3-4), pp. 216
Lauriello, M., Mazzotta, G., Mattei, A., ... Iacomino, E., Eibenstein, A. Assessment of Executive Functions in Children with Sensorineural Hearing Loss and in Children with Specific Language Impairment: Preliminary Reports. Brain Sciences, 2024, 14(5), 491
Iacomino, E., D’amario, M., Tucci, C., ... Sollima, L., Capogreco, M. An unexpected synovial sarcoma of the parotid gland: a rare localization Journal of Biological Regulators and Homeostatic Agents, 2022, 36, pp. 71–79
Iacomino, E., Sinatti, G., Pasqua, M., ... Cipolloni, G., Marco, G.-P.D. Anisakis in oral cavity: A rare case of an emerging disease Oral and Maxillofacial Surgery Cases, 2020, 6(1), 100136
Litta, F., Memè, L., Grilli, F., ... Bambini, F., Mummolo, S.
RARE ODONTOSTOMATOLOGY COMPLICATION ASSOCIATED WITH DISLOCATION OF A SILASTIC NASAL SPLINT: A CASE REPORTn Bulletin of Stomatology and Maxillofacial Surgery, 2023, 19(4), pp. 83–90
Giovannetti, F., Lupi, E., Di Giorgio, D., ... Petricca, G., Valentini, V.
Impact of COVID19 on Maxillofacial Fractures in the Province of L'Aquila, Abruzzo, Italy. Review of 296 Patients Treated with Statistical Comparison of the Two-Year Pre-COVID19 and COVID19 Journal of Craniofacial Surgery, 2022, 33(4), pp. 1182–1184
Di Somma, L., Iacoangeli, M., Nasi, D., ... Polonara, G., Scerrati, M.
Combined supra-transorbital keyhole approach for treatment of delayed intraorbital encephalocele: A minimally invasive approach for an unusual complication of decompressive craniectomy Surgical Neurology International, 2016, 7, pp. S12–S16
Franco, R., Rosa, A., Lupi, E., Capogreco, M. The Influence of Dental Implant Roughness on Biofilm Formation: A Comprehensive Strategy Dental Hypotheses, 2023, 14(3), pp. 90–92
Mannino, M., Lupi, E., Bernardi, S., Becelli, R., Giovannetti, F.
Vascular complications with necrotic lesions following filler injections: Literature systematic review Journal of Stomatology, Oral and Maxillofacial Surgery, 2024, 125(5), 101499
Bernardi, S., Bianchi, S., Lupi, E., ... Macchiarelli, G., Varvara, G.Plasmacytoma in the Maxillary Jaw: A Diagnostic and Therapeutic Challenge Hematology Reports, 2024, 16(1), pp. 22–31
Oliva, S., Capogreco, M., Murmura, G., ... Mariachiara, D.C., D’Amario, M.
The socket shield technique and its complications, implant survival rate, and clinical outcomes: a systematic review Journal of Periodontal and Implant Science, 2022, 52, e32
Messi, M., Consorti, G., Lupi, E., ... Valassina, D., Balercia, P.
A new operative open-wings technique to correct the front forehead unit in metopic synostosis. The Journal of Craniofacial Surgery, 2015, 26(3), pp. 902–905
Quinzi, V., Tecco, S., Nota, A., ... Mummolo, S., Marzo, G. Mesial rotation of the upper first molar: Association with anterior dental crowding in mixed and permanent dentition Applied Sciences (Switzerland), 2020, 10(15), 5301
Mummolo, S., Severino, M., Campanella, V., ... Quinzi, V., Marchetti, E.
Periodontal disease in subjects suffering from coronary heart disease
Journal of Biological Regulators and Homeostatic Agents, 2019, 33(3), pp. 73–82
Saccomanno, S., Mummolo, S., Giancaspro, S., ... Marzo, G., Quinzi, V.
Catering work profession and medico-oral health: A study on 603 subjects
Healthcare (Switzerland), 2021, 9(5), 582
Pennazza, G., Marchetti, E., Santonico, M., ... D'Amico, A., Di Natale, C.
Application of a quartz microbalance-based gas sensor array for the study of halitosis
Journal of Breath Research, 2008, 2(1), 017009
Saccomanno, S., Mummolo, S., Laganà, D., ... Marzo, G., Quinzi, V.
The digital diagnostic approach to Stafne’s bone cavity (Sbc): From a review of the literature to the description of a clinical case
Open Dentistry Journal, 2021, 15(Special Issue), pp. 111–119
Mummolo, S., Ortu, E., Necozione, S., Monaco, A., Marzo, G. Relationship between mastication and cognitive function in the elderly in L'Aquila International Journal of Clinical and Experimental Medicine, 2014, 7(4), pp. 1040–1046
Mancini, L., Tarallo, F., Quinzi, V., ... Mummolo, S., Marchetti, E.
Platelet-rich fibrin in single and multiple coronally advanced flaps for type 1 recession: An updated systematic review and meta-analysis Medicina (Lithuania), 2021, 57(2), pp. 1–20, 144
Dinoi, M.T., Mummolo, S., Monaco, A., ... Campanella, V., Marzo, G.
Correction to: Orthodontic treatment of the transposition of a maxillary canine and a first premolar: a case report (Journal of Medical Case Reports (2015) 9 (48) DOI: 10.1186/s13256-015-0521-z)
Journal of Medical Case Reports, 2019, 13(1), 68
Giuca, M.R., Pasini, M., Pagano, A., Mummolo, S., Vanni, A.
Longitudinal study on a rehabilitative model for correction of atypical swallowing.
European journal of paediatric dentistry: official journal of European Academy of Paediatric Dentistry, 2008, 9(4), pp. 170–174
Memè, L., Strappa, E.M., Monterubbianesi, R., Bambini, F., Mummolo, S.
SEM and FT-MIR Analysis of Human Demineralized Dentin Matrix: An In Vitro Study
Applied Sciences (Switzerland), 2022, 12(3), 1480
Candotto, V., Oberti, L., Gabrione, F., ... Romano, M., Mummolo, S.
Current concepts on cleft lip and palate etiology
Journal of Biological Regulators and Homeostatic Agents, 2019, 33(3), pp. 145–152
Matteo Palmacci, Marco Saverino, Gian Luca Pancrazi, Costanza Ferraro, Lara Ceresoli, Umberto Manica, Matteo Nagni
Aesthetic rehabilitation in lower mandibular area for agenesis in site 4.2: a case report and literature review
ORAL and Implantology Vol. 16 No. 1 (2024) https://doi.org/10.11138/oi1613-6
Bianca D’Orto, Carlo Chiavenna, Renato Leone, Martina Longoni, Matteo Nagni and Paolo Capparè
Marginal Bone Loss Compared in Internal and External Implant Connections: Retrospective Clinical Study at 6-Years Follow-Up Biomedicines 2023, 11(4), 1128; https://doi.org/10.3390/biomedicines11041128
Paolo Capparè, Giulia Tetè, Bianca D’Orto, Matteo Nagni and Enrico Felice Gherlone
Immediate Loaded Full-Arch Mandibular Rehabilitations in Younger vs. Elderly Patients: A Comparative Retrospective Study with 7-Year Follow-Up J. Clin. Med. 2023, 12(13), 4524; https://doi.org/10.3390/jcm12134524
Matteo Nagni, Filippo Pirani, Bianca D’Orto, Francesco Ferrini and Paolo Cappare
Clinical and Radiographic Follow-Up of Full-Arch Implant Prosthetic Rehabilitations: Retrospective Clinical Study at 6-Year Follow-Up
Appl. Sci. 2023, 13(20), 11143; https://doi.org/10.3390/app132011143
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Eduardo Basáñez Ribera, Raymundo Ramírez Lugo, Ettore Lupi, Gianluca Botticelli, Stefano Mummolo, Thomas W. Graber, Giovani Falisi